Effect of Antioxidant Activity of Naringin and CoQ10 Against Acetaminophen-Induced Nephrotoxicity in Male Rats

Huda Sahib Abd AL-Rasool and Saher Mahmood Jwad

References:

1. V. Lobo, A. Patil, A. Phatak, and N. Chandra, "Free radicals, antioxidants and functional foods: Impact on human health," Pharmacognosy Reviews, vol. 17, no. 34, pp. 118-126, 2023.
2. L. A. Pham-Huy, H. He, and C. Pham-Huy, "Free radicals, antioxidants in disease and health," International Journal of Biomedical Science, vol. 18, no. 2, pp. 95-110, 2022.
3. C. Caglayan, Y. Temel, F. M. Kandemir, S. Yildirim, and S. Kucukler, "Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy, and DNA damage," Environmental Science and Pollution Research, vol. 25, pp. 20968-20984, 2018.
4. B. D. Sahu, S. Tatireddy, M. Koneru, R. M. Borkar, J. M. Kumar, M. Kuncha, and R. Sistla, "Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: possible mechanism of nephroprotection," Toxicology and Applied Pharmacology, vol. 277, no. 1, pp. 8-20, 2014.
5. K. Shirani, B. S. Yousefsani, and M. Shirani, "Protective effects of naringin against drugs and chemical toxins induced hepatotoxicity: a review," Phytotherapy Research, vol. 34, no. 8, pp. 1734-1744, 2020.
6. A. Di Lorenzo, G. Iannuzzo, A. Parlato, G. Cuomo, C. Testa, M. Coppola, and F. Giallauria, "Clinical evidence for Q10 coenzyme supplementation in heart failure: from energetics to functional improvement," Journal of Clinical Medicine, vol. 9, no. 5, p. 1266, 2020.
7. N. S. Al-Johani, M. Al-Zharani, N. H. Aljarba, N. M. Alhoshani, N. Alkeraishan, and S. Alkahtani, "[Retracted] Antioxidant and Anti‐Inflammatory Activities of Coenzyme‐Q10 and Piperine against Cyclophosphamide‐Induced Cytotoxicity in HuH‐7 Cells," BioMed Research International, vol. 2022, no. 1, p. 8495159, 2022.
8. I. Hargreaves, D. Mantle, and D. Milford, "Chronic kidney disease and coenzyme Q10 supplementation," Journal of Kidney Care, vol. 4, no. 2, pp. 82-90, 2019.
9. C. Bunchorntavakul and K. R. Reddy, "Acetaminophen-related hepatotoxicity," Clinics in Liver Disease, vol. 17, no. 4, pp. 587-607, 2013.
10. C. I. Ghanem, M. J. Pérez, J. E. Manautou, and A. D. Mottino, "Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity," Pharmacological Research, vol. 109, pp. 119-131, 2016.
11. A. K. Rad, R. Mohebbati, and S. Hosseinian, "Drug-induced nephrotoxicity and medicinal plants," Iranian Journal of Kidney Diseases, vol. 11, no. 3, p. 169, 2017.
12. S. Roy, S. Pradhan, K. Das, A. Mandal, S. Mandal, A. Patra, A. Samanta, B. Sinha, and D. K. Nandi, "Acetaminophen-induced kidney failure in rats: A dose-response study," Journal of Biological Sciences, vol. 15, no. 4, pp. 187-193, 2015.
13. X. J. Dai, Y. Jia, R. Cao, and M. N. Zhou, "Naringin prevents cognitive dysfunction in aging rats by inhibiting Toll‐like receptor 4 (TLR4)/NF‐κB pathway and endoplasmic reticulum stress," Evidence-Based Complementary and Alternative Medicine, vol. 2023, no. 1, p. 2919811, 2023.
14. M. Hossain, T. Tanjim, F. Samiha, M. Islam, F. Abdullah, J. Hasan, S. M. C. Rahman, M. Bepari, H. Rahman, and M. Reza, "Coenzyme Q10 ameliorates carbofuran-induced hepatotoxicity and nephrotoxicity in Wistar rats," Heliyon, vol. 9, no. 2, p. e13727, 2023.
15. N. W. Tietz, Clinical Guide to Laboratory Tests, 4th ed. Philadelphia, PA: W.B. Saunders Co., 2006.
16. N. W. Tietz, Textbook of Clinical Chemistry, 3rd ed. C. A. Burtis and E. R. Ashwood, Eds. Philadelphia, PA: W.B. Saunders, pp. 282-884, 1429-1431, 1999.
17. B. Guidet and S. V. Shah, "Am J. Physiol 257 (26), F440," cited by R. K. Muslih, M. S. Al-Nimer, and O. Y. Al-Zamely, "The level of Malondialdehyde after activation with H₂O₂ and CuSO₄ and inhibition by deferoxamine and Molsidomine in the serum of patient with acute Myocardial infarction," National Journal of Chemistry, vol. 5, pp. 139-148, 2002.
18. D. R. Spitz and L. W. Oberley, "An assay for superoxide dismutase activity in mammalian tissue homogenates," Anal. Biochem., vol. 179, no. 1, pp. 8-18, 1989.
19. D. Labbe, A. Vassault, B. Cherruau, P. Baltassat, R. Bonete, G. Carroger, A. Costantini, S. Guerin, O. Houot, B. Lacour, A. Nicolas, E. Thioulouse, and D. Trepo, "Method selected for the determination of creatinine in plasma or serum. Choice of optimal conditions of measurement (in French)," Ann. Biol. Clin., vol. 54, pp. 285-298, 1996.
20. P. Shipping, C. Company, and D. Entery, "Standard Operating Procedures," Stand. Opera. Proced., vol. 10, no. 1, pp. 56-57, 2006.
21. M. Weissman, V. J. Pileggi, R. J. Henry, D. C. Cannon, and J. W. Winkelman, Clinical Chemistry: Principles and Techniques, 11th ed. Hagerstown, MD: Harper & Row, 1974, p. 655.
22. G. A. Morgan, N. A. Leech, G. W. Gleaner, and K. C. Barrett, SPSS for Introductory Statistics: Use and Interpretation, 2nd ed. Mahwah, NJ, London: Lawrence Erlbaum Associates, 2010.
23. S. Sabiu, F. H. O’Neill, and A. O. T. Ashafa, "The purview of phytotherapy in the management of kidney disorders: a systematic review on Nigeria and South Africa," Afr. J. Tradit. Complement. Altern. Med., vol. 13, no. 5, pp. 38-47, 2016.
24. D. Taj, A. Tariq, V. Sultana, J. Ara, V. U. Ahmad, and S. Ehteshamul-Haque, "Protective role of Stokeyia indica in liver dysfunction and associated complications in acetaminophen-intoxicated rats," Clin. Phytosci., vol. 5, no. 28, pp. 1-8, 2019.
25. N. H. Farhan, B. L. Aziz, R. T. Ibraheem, and N. H. Farhan, "Biochemical evaluation of the hepatoprotective potential of lemon oil and Nigella sativa oil in acetaminophen-induced liver injury," Kerbala J. Pharm. Sci., pp. 258-268, 2024.
26. S. Roy, S. Pradhan, K. Das, A. Mandal, S. Mandal, A. Patra, A. Samanta, B. Sinha, and D. K. Nandi, "Acetaminophen-induced kidney failure in rats: A dose-response study," J. Biol. Sci., vol. 15, no. 4, pp. 187-193, 2015.
27. J. Zhang, C. Xing, H. Zhao, and B. He, "The effectiveness of coenzyme Q10, vitamin E, inositols, and vitamin D in improving the endocrine and metabolic profiles in women with polycystic ovary syndrome: A network meta-analysis," Gynecol. Endocrinol., vol. 37, no. 12, pp. 1063-1071, 2021.
28. H. Chtourou, "Credit markets and financial crisis in the USA," Int. J. Comput. Econ. Econometrics, vol. 6, no. 2, pp. 192-209, 2016.
29. Y. R. Ahmed, A. F. Aboul Naser, M. M. Elbatanony, A. M. El-Feky, W. K. Khalil, and M. A. A. Hamed, "Gene expression, oxidative stress, and neurotransmitters in rotenone-induced Parkinson’s disease in rats: Role of naringin from Citrus aurantium via blocking adenosine A2A receptor," Curr. Bioact. Compd., vol. 20, no. 5, pp. 1-16, 2024.
30. C. U. Igwe, L. A. Nwaogu, E. U. Olunkwa, M. A. Otaba, and N. Nwachukwu, "Multi-organ protective effect of aqueous leaf extracts of Euphorbia heterophylla and Jatropha curcas against paracetamol-induced toxicity in albino rats," J. Forensic Sci. Toxicol., vol. 2, no. 1, pp. 1007, 2019.
31. J. M. Lopez-Novoa, Y. Quiros, L. Vicente, A. I. Morales, and F. J. Lopez-Hernandez, "New insights into the mechanism of aminoglycoside nephrotoxicity: An integrative point of view," Kidney Int., vol. 79, no. 1, pp. 33-45, 2011.
32. A. Ishikawa, H. Kawarazaki, K. Ando, M. Fujita, T. Fujita, and Y. Homma, "Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10," Clin. Exp. Nephrol., vol. 15, pp. 30-33, 2011.
33. M. M. Khadairi, A. O. Hussein, and M. J. Y. Al-Amari, "Study of protective effect of vitamin C in reduction toxicity of malathion in white albino mice," Plant Arch., vol. 18, no. 1, pp. 469-475, 2018.
34. H. A. Shamardl, S. M. El-Ashmony, H. F. Kamel, and S. H. Fatani, "Potential cardiovascular and renal protective effects of vitamin D and coenzyme Q10 in L-NAME-induced hypertensive rats," Am. J. Med. Sci., vol. 354, no. 2, pp. 190-198, 2017.
35. M. M. Ali, O. M. Ahmed, A. S. Nada, E. S. Abdel-Reheim, and N. E. Amin, "Possible protective effect of naringin (a citrus bioflavonoid) against kidney injury induced by γ-irradiation and/or iron overload in male rats," Int. J. Radiat. Res., vol. 18, no. 4, pp. 673-684, 2020.
36. V. S. Shilpa, R. Shams, K. K. Dash, V. K. Pandey, A. H. Dar, S. Ayaz Mukarram, and B. Kovács, "Phytochemical properties, extraction, and pharmacological benefits of naringin: A review," Molecules, vol. 28, no. 15, p. 5623, 2023.
37. M. Adil, A. D. Kandhare, P. Ghosh, S. Venkata, K. S. Raygude, and S. L. Bodhankar, "Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: Role of FXR and KIM-1," Renal Failure, vol. 38, no. 6, pp. 1007-1020, 2016.
38. M. L. Nor Muhamad, S. O. Ekeuku, S. K. Wong, and K. Y. Chin, "A scoping review of the skeletal effects of naringenin," Nutrients, vol. 14, no. 22, p. 4851, 2022.