Tamarind contains a good amount of bioactive components with potential health benefits. Therefore, the current study was conducted to analyze the antioxidant effects of tamarind fruit extracts in alloxan-induced diabetic rats. The number of experimental rats was 49, which were distributed into seven groups: Group 0 (G0) as a control group, Group 1 (G1) as a diabetic group, Groups 2 and 3 (G2 and G3) as diabetic treatment groups that received aqueous (G2) and ethanolic (G3) tamarind extracts at a dose of 500 mgkg-1 body weight, and Groups 4 and 5 (G4 and G5) as non-diabetic groups that received (aqueous tamarind extract G4, at 500 mgkg-1 body weight) and (ethanolic tamarind extract G5, at 500 mgkg-1 body weight). Group 6 (G6), the diabetic, was treated with insulin at a dose of 6 IU/kg body weight, with all groups having access to food and water ad libitum, and the study period was 30 days. At the study's conclusion, the rats were euthanized, and their serum samples were analyzed for biomarkers, including liver enzymes (ALT, AST, ALP), kidney markers (creatinine and urea), antioxidant enzymes (SOD, CAT and GPx), and an indicator of oxidative stress (MDA). The results showed that administration of tamarind extracts (500 mgkg-1 body weight) led to a significant reduction in the liver enzymes levels, creatinine, urea, and MDA in the serum of diabetic rats (G2 and G3), compared to the diabetic group (G1), which exhibited elevated levels of these biomarkers. The results indicate that tamarind extracts possess antioxidant and hepatic and renal-protective properties, mitigating alloxan-induced oxidative stress and organ damage.
D. A. Almalki, S. A. Alghamdi, and A. M. Al-Attar, "Comparative study on the influence of some medicinal plants on diabetes induced by streptozotocin in male rats," Biomed. Res. Int., vol. 2019, p. 3596287, 2019.
K. Ogurtsova, L. Guariguata, N. C. Barengo, P. L. Ruiz, J. W. Sacre, S. Karuranga, H. Sun, E. J. Boyko, and D. J. Magliano, "IDF diabetes atlas: global estimates of undiagnosed diabetes in adults for 2021," Diabetes Res. Clin. Pract., vol. 183, p. 109118, 2022.
M. L. Willcox, C. Elugbaju, M. Al-Anbaki, M. Lown, and B. Graz, "Effectiveness of medicinal plants for glycaemic control in type 2 diabetes: an overview of meta-analyses of clinical trials," Front. Pharmacol., vol. 12, p. 777561, 2021.
A. R. Chowdhury, B. K. Sarkar, A. Das, S. Halder, R. Akter, A. Sarkar, and S. Kundu, "Antidiabetic properties of some dietary fruits and vegetables commonly used in Bangladesh: a comprehensive review," Int. J. Adv. Res. Pharm. Edu., vol. 2, no. 1, pp. 6–15, 2020.
S. Mahadkar, S. Valvi, and V. Jadhav, "Gas chromatography mass spectroscopic (GCMS) analysis of some bioactive compounds from five medicinally relevant wild edible plants," Asian J. Pharm. Clin. Res., vol. 6, no. 1, pp. 136–139, 2013.
I. Engelbrecht, S. Horn, J. P. Giesy, and R. Pieters, "Determining superoxide dismutase content and catalase activity in mammalian cell lines," MethodsX, vol. 11, p. 102395, 2023.
E. D. N. S. Abeyrathne, K. Nam, and D. U. Ahn, "Analytical methods for lipid oxidation and antioxidant capacity in food systems," Antioxidants, vol. 10, no. 10, p. 1587, 2021.
A. Pashapoor, S. Mashhadyrafie, and P. Mortazavi, "Ameliorative effect of Myristica fragrans (nutmeg) extract on oxidative status and histology of pancreas in alloxan-induced diabetic rats," Folia Morphol. (Warsz), vol. 79, no. 1, pp. 113–119, 2020.
J. Juśkiewicz, A. Jurgonski, K. Kołodziejczyk, M. Kosmala, J. Milala, and Z. Zduńczyk, "Blood glucose-lowering efficacy of strawberry extracts rich in ellagitannins with different degrees of polymerization in rats," Pol. J. Food Nutr. Sci., vol. 66, no. 2, pp. 109–117, 2016.
R. S. Abboud, I. C. A. Ribeiro, V. A. Pereira, L. B. N. Corrêa, G. T. Boaventura, and M. A. Chagas, "Guarana (Paullinia cupana) consumption improves hepatic and renal parameters in alloxan-induced diabetic rats," Nutr. Hosp., vol. 37, no. 2, pp. 343–348, 2020.
Y. Zheng, A. F. El-Kott, F. Shaldoum, D. Massoud, Y. Pan, and E. R. Elbealy, "Alleviation of diabetes-induced hepatotoxicity by date palm hydroalcoholic extract in rat model: a biochemical, immunohistochemical and stereological study," Int. J. Morphol., vol. 39, no. 3, pp. 876–885, 2021.
S. Radha and S. Kusum, "Traditional, pharmacological, and therapeutic properties of Tamarindus indica," J. Plant Sci. Res., vol. 11, no. 1, pp. 257–263, 2024.
M. A. Al-Ahdab, "Anti-hyperglycemic effect of Tamarindus indica extract in streptozotocin-induced diabetes in male rats," World Appl. Sci. J., vol. 33, no. 12, pp. 1940–1948, 2015.
E. L. Nolasco, F. L. Zanoni, F. P. Nunes, S. S. Ferreira, L. A. Freitas, M. C. Silva, and J. O. Martins, "Insulin modulates liver function in a type I diabetes rat model," Cell. Physiol. Biochem., vol. 36, no. 4, pp. 1467–1479, 2015.
O. Sekiou, M. Boumendjel, F. Taibi, L. Tichati, A. Boumendjel, and M. Messarah, "Nephroprotective effect of Artemisia herba alba aqueous extract in alloxan-induced diabetic rats," J. Tradit. Complement. Med., vol. 11, no. 1, pp. 53–61, 2020.
R. Delfita, D. Dahelmi, D. Tjong, and S. Suhatri, "Effect of Enhydra fluctuans on kidney function in alloxan-induced diabetic rats," Open Access Maced. J. Med. Sci., vol. 9, no. A, pp. 1187–1194, 2021.
O. Abu, E. P. Awhin, and H. Iyare, "Assessment of renal function in diabetic Wistar rats treated with ethanol extract of Cucumis sativus fruit," Afr. J. Health Safety Environ., vol. 4, no. 1, pp. 101–107, 2023.
R. Jha, S. Lopez-Trevino, H. R. Kankanamalage, and J. C. Jha, "Diabetes and renal complications: an overview on pathophysiology, biomarkers and therapeutic interventions," Biomedicines, vol. 12, no. 5, p. 1098, 2024.
M. El-Shaer, L. Diab, and S. M. A. A. Abdalla, "Potential effect of red pitaya fruit on alloxan-induced diabetic rats," J. Home Econ. Menofia Univ., vol. 33, no. 1, pp. 89–101, 2023.
A. Caturano, M. D'Angelo, A. Mormone, V. Russo, M. P. Mollica, T. Salvatore, R. Galiero, V. Rinaldi, E. Vetrano, R. Marfella, M. Monda, A. Giordano, and F. C. Sasso, "Oxidative stress in type 2 diabetes: impacts from pathogenesis to lifestyle modifications," Curr. Issues Mol. Biol., vol. 45, no. 8, pp. 6651–6666, 2023.
L. S. Borquaye, M. S. Doetse, S. O. Baah, and J. A. Mensah, "Anti-inflammatory and antioxidant activities of ethanolic extracts of Tamarindus indica L. (Fabaceae)," Cogent Chem., vol. 6, no. 1, p. 1743403, 2020.
B. Devi and T. Boruah, "Antioxidants in fruits: properties and health benefits, chapter 16 Tamarind (Tamarindus indica)," in Springer Nature Singapore Pte Ltd., 2020, pp. 317–332.
K. O. Fagbemi, D. A. Aina, M. O. Adeoye-Isijola, K. K. Naidoo, R. M. Coopoosamy, and O. O. Olajuyigbe, "Bioactive compounds, antibacterial and antioxidant activities of methanol extract of Tamarindus indica Linn.," Sci. Rep., vol. 12, no. 1, p. 9432, 2022.
M. Al Abboud, K. Ismail, A. Mashraqi, S. Albishi, A. Al-Namazi, and Y. Masrahi, "GC-MS analysis and antibacterial activities of some plants belonging to the genus Euphorbia on selected bacterial isolates," Open Chem., vol. 21, no. 1, p. 20220325, 2023.
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