Proceedings of International Conference on Applied Innovation in IT
2025/06/27, Volume 13, Issue 2, pp.623-633
Synthesis, Spectral Characterisation and Biological Evaluation of a New Azo-Ligand Derived from Aminoacetophenone with its Metal Complexes
Mohammed Qays Mezher and Enaam Ismail Yousif Abstract: Synthesis and characterisation of a new azo ligand based on a 4-aminoacetophenone moiety, along with its metal complexes. The synthesis of the ligand, ((E)-3-((4-acetylphenyl)diazenyl)-2-hydroxy-1-naphthaldehyde) (HL), was obtained from the interaction of 4-aminoacetophenone with 2-hydroxynaphthalene-1-carbaldehyde in a one-to-one molar ratio. Subsequently, the interaction of HL with various metal ions (Cr(Ш), Mn(II), Co(II), Ni(II) and Cu(II) in the ratio of one ligand to one metal, produced monomeric coordination connections. These compounds have been fully characterised using analytical methods and spectroscopic techniques, involve elemental microanalysis,1H and 13C-nuclear magnetic resonance, Fourier transform infrared spectroscopy, electronic and mass spectroscopy, as well as magnetic susceptibility and Conductivity measurements. The analytical data verified the formation of coordination compounds exhibiting six-coordinate geometries. The antibacterial evaluation of the ligand and its coordination complexes against bacterial strains and fungus species showed a significant enhancement in the effectiveness of the antimicrobial ligand when forming complexes with metal ions. In addition, the study evaluated the antibacterial activity of synthesised compounds with a number of bacteria and fungi. The complex formation significantly enhanced the antibacterial efficacy of the ligand.
Keywords: ((E)-3-((4-Acetylphenyl)Diazenyl)-2-Hydroxy-1-Naphthaldehyde); Metal Complexes; Azo Ligand; Proteus Mirailis; 4-Aminacetophenone.
DOI: 10.25673/120550
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