Proceedings of International Conference on Applied Innovation in IT · 2026/03/31 · Vol. 14 · Issue 1 · pp. 783–789
Experimental Study of the Protective Effects of Capparis spinosa Aqueous Extract on Carbon Tetrachloride-Induced Toxicity in Female Rabbits
Mohammed Bouskout, Khalid Dfeek Ahmed, Luay Qasim Abdulhameed, Aseel J. Kadim, Anaam Fuad Hussain, Mohammed Waheeb Mahdi, Rusul Mahdy Salih and Hayam Mohammed Abo Elmaaty
This study investigates the protective potential of an aqueous extract of Capparis spinosa against carbon tetrachloride (CCl₄)-induced toxicity and its effects on selected hematological and biochemical parameters in female rabbits. Twelve rabbits were randomly assigned into three groups (n = 4 per group): a control group receiving a standard diet, and two experimental groups administered CCl₄ at doses of 0.2 mL/kg and 0.3 mL/kg, respectively. After a three-week exposure period, the experimental groups were subsequently treated with Capparis spinosa aqueous extract for three weeks at doses of 2 mL and 3 mL, respectively. Hematological indices (RBC, WBC, Hb, lymphocytes, platelets) and biochemical markers (glucose, cholesterol, triglycerides, total protein, urea, ALT, AST, and ALP) were evaluated. The results indicated that CCl₄ exposure induced significant alterations in both hematological and biochemical parameters, including reductions in RBC, Hb, WBC, and lymphocyte counts, as well as elevated liver enzyme activity. Treatment with the plant extract showed partial restorative effects, improving RBC, platelet counts, and reducing ALT levels. However, disturbances in lipid and protein metabolism persisted. Overall, the findings suggest that Capparis spinosa exhibits partial hepatoprotective and hematopoietic effects against CCl₄-induced toxicity, supporting its potential as a natural antioxidant-based therapeutic agent.
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