Proceedings of International Conference on Applied Innovation in IT  ·  2026/03/31  ·  Vol. 14  ·  Issue 1  ·  pp. 923–932
Bioinformatics Analysis of Noval SNPs Polymorphism with Haplotypes of Mucin-1 Gene Associated with Infertility
Asmaa M. Salih Almohaidi, Abeer Abdulhameed Faisal, Mohanad Waheeb Mahdi and Shumaila Ijaz
📄 Download PDF DOI: 10.25673/123655
Abstract
Mucin one (MUC1) is a protein coding gene which located on long arm of chromosome 1 in region2 band 2 (1q22). The current novel study examines the relation of many new variation MUC1 polymorphisms, haplotype and infertility in females. The study included one hundred and twenty women, sixty women with infertility and sixty healthy fertile women. This study analysis sequencing of specific segments (876 bp) at exon (3-6) of MUC1 gene to examine polymorphism for new specific suggested SNPs and haplotype. The current study investigated fife new suggested SNPs in MUC1 gene. The new suggested SNP 155187497 GG homozygous genotype showed a significant protective association with infertility with a 0.31 odds ratio while the GA heterozygous genotype showed a significant risky association with a 3.05 odds ratio. In contrast, the AA homozygous genotype exhibited nonsignificant risky effects with 3.05 odds ratio associated with infertility. These finding suggest that the G allele acted as a protective allele, while the A allele may be associated with the infertility. The other four new suggested SNPs 155187477, 155187668, 155187698 and 155187793 of MUC1 gene showed no significant differences between infertile and fertile women. In addition, three suggested SNPs (155187668, 155187698 and 155187793) and two suggested SNPs (155187477 and 155187668) in the MUC1 gene demonstrated significant linkage disequilibrium LD with one another.
Keywords
Infertility Polymorphism and Haplotype Newly Snps MUC1 Gene.
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