In this study, oxazepine and diazepine compounds were prepared, which are non-homogeneous seven-membered ring compounds. The oxazepane derivatives were prepared using diamine compounds with dicarboxylic compounds to produce anile compound that it used in preparation of oxazepane through cyclization reaction, then the product reacted with amine derivative to yield diazepine derivatives. Most of the seven-membered rings that were prepared had high effectiveness in pharmaceutical studies similar to what those rings contain of hybrid nitrogen atoms such as oxygen and nitrogen, which are medically known to have entered the fields of drug manufacturing and the field of antioxidant manufacturing, so researchers used them in several techniques such as polymeric drug carrier technology and others, Many researchers have succeeded in linking seven-ring molecules to produce anticancer drugs, the effectiveness of which has been demonstrated through molecular docking programs and other pharmaceutical programs that enhance practical studies, These compounds are characterized by high activity and efficacy, as demonstrated by studies using FT-IR, 1H-NMR, and 13C-NMR techniques. By verifying the chemical structure of these compounds, it was found that these derivatives have biological activity such anticancer activity and can be used as medical drugs against certain diseases, in addition to the use of their derivatives in polymers.