Proceedings of International Conference on Applied Innovation in IT
2025/06/27, Volume 13, Issue 2, pp.745-752

Investigating Myo-Inositol Oxygenase and Renal Biomarkers in Acute Kidney Injury


Abdullah Abdulsattar Raeef, Abdulla A. Al-dulaimi and Bilal A. Dylan


Abstract: Acute kidney injury (AKI) refers to an abrupt renal damage episode or failure, which can occur within a few hours or days. Myo-inositol oxygenase (MIOX) is an enzyme involved in the breakdown of myo-inositol. MIOX catalyzes the oxidation of myo-inositol to form D-glucuronate, an important step in the metabolism of myo-inositol. Research has suggested potential links between MIOX and kidney function. The objective of this study to show the role of MIOX on kidney diseases. Methods: Case-control study was conducted in Anbar Dialysis Center. 50 participants suffering from AKI and the other group of 50 participants of healthy participants. Demographic information for both groups was obtained (age, Body Mass Index "BMI", duration of disease), in addition to laboratory tests (urea, creatinine, uric acid, calcium, and MIOX). Groups were compared using the t‑test and descriptive analysis. Pearson’s correlation coefficient was used to find the relationship between different variables. Results: In this case-control study Urea, creatinine, and uric acid have higher concentrations and are statistically significant in acute kidney injury cases than in healthy controls. In addition to a decrease in the concentration of calcium and MIOX with high significant differences between the two groups. Conclusion: Acute kidney injury is associated with an elevation in urea, creatinine, and uric acid and a decrease in calcium and MIOX. Studies have shown that MIOX expression levels are up-regulated in response to renal injury, suggesting a role for this enzyme in the pathogenesis of AKI.

Keywords: Acute Kidney Injury, Myo-Inositol Oxygenase, Kidney Functions, Kidney Diseases.

DOI: Under Indexing

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